TY - JOUR T1 - Plasma Catalase in Relation to Pain Following Midline Laparotomy: A Prospective Study of Patients with Benign Diseases and Patients with Cancer JF - Anticancer Research JO - Anticancer Res SP - 6479 LP - 6484 DO - 10.21873/anticanres.13011 VL - 38 IS - 11 AU - IINA SAIMANEN AU - JARI KÄRKKÄINEN AU - TUOMAS SELANDER AU - MARTIN PURDY AU - MERJA KOKKI AU - HANNU KOKKI AU - MATTI ESKELINEN Y1 - 2018/11/01 UR - http://ar.iiarjournals.org/content/38/11/6479.abstract N2 - Background/Aim: The relationship of plasma concentrations of the oxidative stress biomarker catalase with pain on numeric rating scale at rest (NRSr) and under wound pressure 24 hours postoperatively (NRSp) in midline laparotomy patients with rectus sheath block (RSB) analgesia are unknown. Our original hypothesis was that RSB analgesia might reduce postoperative pain. Patients and Methods: Initially, 56 patients were randomized to four groups: control group (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) RSB analgesia groups. The plasma concentrations of catalase were measured immediately before, immediately after and 24 hours after surgery. The pain at rest and under pressure were scored on an 11-point numeric rating scale 24 hours postoperatively (NRSr and NRSp; 0: no pain; 10: worst pain). Results: The median plasma concentration of catalase increased immediately after surgery (p=0.007), but then decreased 24 hours postoperatively compared with immediately after surgery (p<0.001). The control group and the RSB groups did not differ in individual NRSr and NRSp values following surgery. Scatter plots of the plasma catalase versus superoxide dismutase concentrations were positively correlated in the patients (r=0.314, p<0.001). In addition, scatter plots of the individual NRSr and NRSp values versus plasma values of catalase were inversely correlated in patients (r=−0.221, p=0.03 and r=−0.238, p=0.02, respectively). Conclusion: The RSB analgesia does not reduce postoperative pain. Plasma catalase levels and pain following surgery are significantly correlated in patients regardless of disease type. ER -