TY - JOUR T1 - Hairy Cell Leukemia: Retrospective Analysis of Demographic Data and Outcome of 203 Patients from 12 Medical Centers in Israel JF - Anticancer Research JO - Anticancer Res SP - 6423 LP - 6429 DO - 10.21873/anticanres.13003 VL - 38 IS - 11 AU - MICHAL INBAR AU - YAIR HERISHANU AU - NETA GOLDSCHMIDT AU - OSNAT BAIREY AU - MONA YUKLEA AU - LEV SHVIDEL AU - RIVA FINEMAN AU - ARIEL AVIV AU - ROSA RUCHLEMER AU - ANDREI BRAESTER AU - DALLY NAJIB AU - ORY ROUVIO AU - ADIR SHAULOV AU - URI GREENBAUM AU - AARON POLLIACK AU - TAMAR TADMOR Y1 - 2018/11/01 UR - http://ar.iiarjournals.org/content/38/11/6423.abstract N2 - Background/Aim: In this retrospective study, we summarized the national Israeli experience with hairy cell leukemia (HCL) in a large cohort of patients with a long follow-up. Patients and Methods: Demographic data, and relevant laboratory and clinical parameters were analyzed, emphasizing the outcome after first-line treatment with cladribine. Results: Data on 203 patients was collected from 12 medical centers during 1985-2015. Mean and median follow-up were 7.5 years and 5.18 years (interquartile range=0.1-40 years), and 5- and 10-year survival were 96% and 90.62%, respectively. The median age of diagnosis was 55.5 years for Jews and 49 years for Arabs (p=0.021), and most patients were males (81.77%); 52.2% were Ashkenazi Jews, 36.1% Sephardic Jews and 11.7% were Arab, Druze or other ethnicity. Cladribine was given to 159 patients (80.7%%) and most (62%) received intravenous (i.v.) and 38% received subcutaneous (s.c.) therapy. Overall survival and time to next treatment were not significantly different between the two schedules (i.v., s.c.). In univariate analysis of a variety of factors, only age >65 years had a negative impact on outcome, with shorter overall survival. It is of interest that Arab patients with HCL were diagnosed at an earlier age, but had a similar clinical course and outcome to both Ashkenazi and Sephardic Jews. ER -