PT  - JOURNAL ARTICLE
AU  - ELBA A. TURBAT-HERRERA
AU  - MATTHEW J. KILPATRICK
AU  - JIE CHEN
AU  - ANDREW T. MERAM
AU  - JAMES COTELINGAM
AU  - GHALI GHALI
AU  - CHRISTOPHER G. KEVIL
AU  - DOMENICO COPPOLA
AU  - RODNEY E. SHACKELFORD
TI  - Cystathione β-Synthase Is Increased in Thyroid Malignancies
AID  - 10.21873/anticanres.12958
DP  - 2018 Nov 01
TA  - Anticancer Research
PG  - 6085--6090
VI  - 38
IP  - 11
4099  - http://ar.iiarjournals.org/content/38/11/6085.short
4100  - http://ar.iiarjournals.org/content/38/11/6085.full
SO  - Anticancer Res2018 Nov 01; 38
AB  - Background: Cystathione β-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway. CBS protein expression levels are increased in several different human malignancies, with increased protein expression correlating with parameters such as tumor stage, anaplasia, metastases, and chemotherapy resistance. Materials and Methods: This study employed tissue microarrays to examine CBS expression in benign thyroid tissue, thyroid oncocytomas, thyroid follicular adenomas, and in follicular, papillary, anaplastic, and medullary thyroid carcinomas. Results: CBS expression was increased in all thyroid carcinomas types compared to benign thyroid tissue, but not in thyroid follicular adenomas or oncocytomas. A similar pattern was observed for nicotinamide phosphoribosyltransferase (NAMPT) tissue microarray analysis comparing thyroid adenomas and follicular carcinomas. Conclusion: For the first time, we showed that an H2S-syntheszing enzyme plays a role in thyroid malignancies. Additionally, our data suggest that CBS and NAMPT immunohistochemistry may be useful in differentiating follicular adenomas from follicular carcinomas.