TY - JOUR T1 - Salvage Carbon-ion Radiotherapy for Isolated Lymph Node Recurrence Following Curative Resection of Esophageal Cancer JF - Anticancer Research JO - Anticancer Res SP - 6453 LP - 6458 DO - 10.21873/anticanres.13007 VL - 38 IS - 11 AU - YUKA ISOZAKI AU - SHIGEO YASUDA AU - YASUNORI AKUTSU AU - HIDEAKI SHIMADA AU - SHINICHI OKAZUMI AU - YOSHIHIRO NABEYA AU - ISAMU HOSHINO AU - KENTARO MURAKAMI AU - DANIEL K. EBNER AU - HIROSHI TSUJI AU - TADASHI KAMADA AU - SHIGERU YAMADA AU - HISAHIRO MATSUBARA Y1 - 2018/11/01 UR - http://ar.iiarjournals.org/content/38/11/6453.abstract N2 - Aim: Evaluation of the therapeutic efficacy of carbon-ion radiation therapy for isolated lymph node recurrence following curative resection of esophageal cancer. Materials and Methods: Ten cases with lymph node recurrence after esophageal cancer surgery were treated with carbon-ion radiation therapy. A total of 48.0 Gy [relative biologic effectiveness (RBE)] was delivered over 3 weeks with a daily dose of 4.0 Gy (RBE). Results: The median follow-up duration was 27.1 months (range=3-92.0 months) after carbon-ion radiation therapy. The local control rates at 2, 3 and 5 years were 92.4%. The overall survival rates at 2, 3 and 5 years were 70.0%, 58.3% and 21.9%. The median survival period was 45.3 months after carbon-ion radiation therapy. There were no toxicities of grade 3 or higher. Conclusion: Carbon-ion radiation therapy may be a safe and effective treatment option for isolated lymph node recurrence after radical surgery for esophageal cancer. ER -