RT Journal Article
SR Electronic
T1 Aggressive Cancer Behavior of Latent Gleason Pattern 5 in Prostatectomy Specimens
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6529
OP 6535
DO 10.21873/anticanres.13018
VO 38
IS 11
A1 TETSUYA FUJIMURA
A1 HIROSHI FUKUHARA
A1 YUTA YAMADA
A1 SATORU TAGUCHI
A1 TORU SUGIHARA
A1 AYA NIIMI
A1 MASAKI NAKAMURA
A1 TOHRU NAKAGAWA
A1 YASUHIKO IGAWA
A1 YUKIO HOMMA
A1 HARUKI KUME
YR 2018
UL http://ar.iiarjournals.org/content/38/11/6529.abstract
AB Background/Aim: The aim of this study was to demonstrate the clinical significance of latent Gleason pattern (GP) 5 occasionally found in prostatectomy specimens. Materials and Methods: Patients (n=605) undergoing radical prostatectomy were classified into three groups according to the presence of GP5 in the biopsy or in the prostatectomy specimens: ‘GP5 negative', absence of GP in both specimens ‘latent GP5’, absence of GP5 in the biopsy specimen, but presense of GP5 in the prostatectomy specimen, and ‘GP5 positive’, presense of GP in both specimens. The characteristics of these three groups were analyzed. Results: There were 381 men in the GP5-negative group, 155 in the latent GP5 group, and 69 in the GP5-positive group. Low- or intermediate-risk for prostate cancer, latent GP5 and surgical margin positivity were independent predictors of biochemical recurrence (Hazard ratio (HR): 3.1, 5.8, respectively, p=0.001, 0.0002, respectively). Conclusion: Latent GP5 is an important prognostic factor that should be evaluated in patients with low- and intermediate-risk for prostate cancer before the initiation of treatment.