PT  - JOURNAL ARTICLE
AU  - TETSUYA FUJIMURA
AU  - HIROSHI FUKUHARA
AU  - YUTA YAMADA
AU  - SATORU TAGUCHI
AU  - TORU SUGIHARA
AU  - AYA NIIMI
AU  - MASAKI NAKAMURA
AU  - TOHRU NAKAGAWA
AU  - YASUHIKO IGAWA
AU  - YUKIO HOMMA
AU  - HARUKI KUME
TI  - Aggressive Cancer Behavior of Latent Gleason Pattern 5 in Prostatectomy Specimens
AID  - 10.21873/anticanres.13018
DP  - 2018 Nov 01
TA  - Anticancer Research
PG  - 6529--6535
VI  - 38
IP  - 11
4099  - http://ar.iiarjournals.org/content/38/11/6529.short
4100  - http://ar.iiarjournals.org/content/38/11/6529.full
SO  - Anticancer Res2018 Nov 01; 38
AB  - Background/Aim: The aim of this study was to demonstrate the clinical significance of latent Gleason pattern (GP) 5 occasionally found in prostatectomy specimens. Materials and Methods: Patients (n=605) undergoing radical prostatectomy were classified into three groups according to the presence of GP5 in the biopsy or in the prostatectomy specimens: ‘GP5 negative', absence of GP in both specimens ‘latent GP5’, absence of GP5 in the biopsy specimen, but presense of GP5 in the prostatectomy specimen, and ‘GP5 positive’, presense of GP in both specimens. The characteristics of these three groups were analyzed. Results: There were 381 men in the GP5-negative group, 155 in the latent GP5 group, and 69 in the GP5-positive group. Low- or intermediate-risk for prostate cancer, latent GP5 and surgical margin positivity were independent predictors of biochemical recurrence (Hazard ratio (HR): 3.1, 5.8, respectively, p=0.001, 0.0002, respectively). Conclusion: Latent GP5 is an important prognostic factor that should be evaluated in patients with low- and intermediate-risk for prostate cancer before the initiation of treatment.