RT Journal Article
SR Electronic
T1 Relationship Between the Structure of Methoxylated and Hydroxylated Flavones and Their Antiproliferative Activity in HL60 Cells
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5679
OP 5684
DO 10.21873/anticanres.12904
VO 38
IS 10
A1 KAWAII, SATORU
A1 ISHIKAWA, YUYA
A1 YOSHIZAWA, YUKO
YR 2018
UL http://ar.iiarjournals.org/content/38/10/5679.abstract
AB As part of our continuing investigation on flavonoid derivatives as potential anticancer substances, a series of methoxylated and hydroxylated flavones was synthesized, and their cytotoxic and anti-proliferative activity was evaluated in leukemic HL60 cells. Their structure-activity relationship was also investigated. The correlation between the methoxylation/hydroxylation pattern and antiproliferative activity revealed the importance of the 5,4’- and 3’,4’-dihydroxyl moieties in flavone nucleus.