PT  - JOURNAL ARTICLE
AU  - KAWAII, SATORU
AU  - ISHIKAWA, YUYA
AU  - YOSHIZAWA, YUKO
TI  - Relationship Between the Structure of Methoxylated and Hydroxylated Flavones and Their Antiproliferative Activity in HL60 Cells
AID  - 10.21873/anticanres.12904
DP  - 2018 Oct 01
TA  - Anticancer Research
PG  - 5679--5684
VI  - 38
IP  - 10
4099  - http://ar.iiarjournals.org/content/38/10/5679.short
4100  - http://ar.iiarjournals.org/content/38/10/5679.full
SO  - Anticancer Res2018 Oct 01; 38
AB  - As part of our continuing investigation on flavonoid derivatives as potential anticancer substances, a series of methoxylated and hydroxylated flavones was synthesized, and their cytotoxic and anti-proliferative activity was evaluated in leukemic HL60 cells. Their structure-activity relationship was also investigated. The correlation between the methoxylation/hydroxylation pattern and antiproliferative activity revealed the importance of the 5,4’- and 3’,4’-dihydroxyl moieties in flavone nucleus.