TY - JOUR T1 - Relationship Between the Structure of Methoxylated and Hydroxylated Flavones and Their Antiproliferative Activity in HL60 Cells JF - Anticancer Research JO - Anticancer Res SP - 5679 LP - 5684 DO - 10.21873/anticanres.12904 VL - 38 IS - 10 AU - SATORU KAWAII AU - YUYA ISHIKAWA AU - YUKO YOSHIZAWA Y1 - 2018/10/01 UR - http://ar.iiarjournals.org/content/38/10/5679.abstract N2 - As part of our continuing investigation on flavonoid derivatives as potential anticancer substances, a series of methoxylated and hydroxylated flavones was synthesized, and their cytotoxic and anti-proliferative activity was evaluated in leukemic HL60 cells. Their structure-activity relationship was also investigated. The correlation between the methoxylation/hydroxylation pattern and antiproliferative activity revealed the importance of the 5,4’- and 3’,4’-dihydroxyl moieties in flavone nucleus. ER -