TY - JOUR T1 - Suboptimal Outcomes in Cutaneous Squamous Cell Cancer of the Head and Neck with Nodal Metastases JF - Anticancer Research JO - Anticancer Res SP - 5825 LP - 5830 DO - 10.21873/anticanres.12923 VL - 38 IS - 10 AU - VAMSI VARRA AU - NEIL M. WOODY AU - CHANDANA REDDY AU - NIKHIL P. JOSHI AU - JESSICA GEIGER AU - DAVID J. ADELSTEIN AU - BRIAN B. BURKEY AU - JOSEPH SCHARPF AU - BRANDON PRENDES AU - ERIC D. LAMARRE AU - ROBERT LORENZ AU - BRIAN GASTMAN AU - BINDU V. MANYAM AU - SHLOMO A. KOYFMAN Y1 - 2018/10/01 UR - http://ar.iiarjournals.org/content/38/10/5825.abstract N2 - Background/Aim: There are limited data regarding survival, failure patterns, and factors associated with disease recurrence in patients with cutaneous squamous cell cancer of the head and neck (cSCC-HN) with nodal metastases. Patients and Methods: A retrospective analysis of patients with cSCC-HN metastatic to cervical and/or parotid lymph nodes treated with surgery and post-operative radiation therapy was performed. Results: This study included 76 patients (57 immunocompetent and 18 immunosuppressed) with a median follow-up of 18 months. Overall survival, disease-free survival (DFS), and disease recurrence (DR) at 2 years was 60%, 49%, and 40%, respectively. Immunosuppressed patients had significantly lower 2-year DFS (28% vs. 55%; p=0.003) and higher DR (61% vs. 34%; p=0.04) compared to immunocompetent patients. Analysis of immunocompetent patients demonstrated extracapsular extension (ECE) as the only factor associated with DR (p<0.0001). Conclusion: Patients with nodal metastases from cSCC-HN have suboptimal outcomes. ECE and immunosuppression were significantly associated with DR. ER -