@article {VARRA5825, author = {VAMSI VARRA and NEIL M. WOODY and CHANDANA REDDY and NIKHIL P. JOSHI and JESSICA GEIGER and DAVID J. ADELSTEIN and BRIAN B. BURKEY and JOSEPH SCHARPF and BRANDON PRENDES and ERIC D. LAMARRE and ROBERT LORENZ and BRIAN GASTMAN and BINDU V. MANYAM and SHLOMO A. KOYFMAN}, title = {Suboptimal Outcomes in Cutaneous Squamous Cell Cancer of the Head and Neck with Nodal Metastases}, volume = {38}, number = {10}, pages = {5825--5830}, year = {2018}, doi = {10.21873/anticanres.12923}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: There are limited data regarding survival, failure patterns, and factors associated with disease recurrence in patients with cutaneous squamous cell cancer of the head and neck (cSCC-HN) with nodal metastases. Patients and Methods: A retrospective analysis of patients with cSCC-HN metastatic to cervical and/or parotid lymph nodes treated with surgery and post-operative radiation therapy was performed. Results: This study included 76 patients (57 immunocompetent and 18 immunosuppressed) with a median follow-up of 18 months. Overall survival, disease-free survival (DFS), and disease recurrence (DR) at 2 years was 60\%, 49\%, and 40\%, respectively. Immunosuppressed patients had significantly lower 2-year DFS (28\% vs. 55\%; p=0.003) and higher DR (61\% vs. 34\%; p=0.04) compared to immunocompetent patients. Analysis of immunocompetent patients demonstrated extracapsular extension (ECE) as the only factor associated with DR (p\<0.0001). Conclusion: Patients with nodal metastases from cSCC-HN have suboptimal outcomes. ECE and immunosuppression were significantly associated with DR.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/10/5825}, eprint = {https://ar.iiarjournals.org/content/38/10/5825.full.pdf}, journal = {Anticancer Research} }