RT Journal Article SR Electronic T1 IL-8-251T>A (rs4073) Polymorphism Is Associated with Prognosis in Gastric Cancer Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5703 OP 5708 DO 10.21873/anticanres.12907 VO 38 IS 10 A1 PATRICIO GONZALEZ-HORMAZABAL A1 SANDRA ROMERO A1 MAHER MUSLEH A1 MARCO BUSTAMANTE A1 JUAN STAMBUK A1 RAUL PISANO A1 ENRIQUE LANZARINI A1 HECTOR CHIONG A1 JORGE ROJAS A1 VICTOR GONZALO CASTRO A1 LILIAN JARA A1 ZOLTAN BERGER YR 2018 UL http://ar.iiarjournals.org/content/38/10/5703.abstract AB Background/Aim: Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polymorphisms are associated with overall survival (OS) in gastric cancer (GC) patients. Patients and Methods: A total of 153 individuals with GC diagnosis were followed-up for at least 2 years. Hazard ratios (HR) were estimated from Cox regression models using SNPs as predictor variables. The following SNPs were genotyped for study using a TaqMan assay: rs16944 (IL1B -511C>T); rs4073 (IL8 -251 T>A); rs2275913 (IL-17 -197G>A); rs1800872 (IL10 -592 C>A); rs1800896 (IL10 -1082A>G); rs28372698 (IL32). Results: Interleukin-8 rs4073 (IL-8 -251T>A) showed association with OS under the dominant model (TA + AA) only when adjusted by clinicopathological variables (HR=1.64, 95%CI=1.05-2.55, p=0.030, q-value=0.18), but not with the univariate model (HR=1.51, 95%CI=0.98-2.31, p=0.062, q-value=0.37). No significant differences were observed after adjusting for population stratification (PC1 and PC2 from Principal Component Analysis using genotypes from Infinium Global Screening Array). After stratification by clinicopathological variables, the association with shorter overall survival was higher among patients with diffuse-type tumors (HR=2.24, 95%CI=1.16-4.45) and patients with tumor size >5 cm (HR=1.79, 95%CI=1.08-2.97). Conclusion: These results suggest a role of IL-8 rs4073 in cancer prognosis. Its use as a prognostic marker of GC survival warrants further investigation.