TY - JOUR T1 - Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 5773 LP - 5782 DO - 10.21873/anticanres.12916 VL - 38 IS - 10 AU - MATTEO SANTONI AU - FRANCESCO PIVA AU - UGO DE GIORGI AU - ALESSANDRA MOSCA AU - UMBERTO BASSO AU - DANIELE SANTINI AU - SEBASTIANO BUTI AU - CRISTIAN LOLLI AU - CARLO TERRONE AU - MARCO MARUZZO AU - MICHELE IULIANI AU - MELISSA BERSANELLI AU - ALESSANDRO CONTI AU - ROBERTA MAZZUCCHELLI AU - RODOLFO MONTIRONI AU - LUCIANO BURATTINI AU - ROSSANA BERARDI Y1 - 2018/10/01 UR - http://ar.iiarjournals.org/content/38/10/5773.abstract N2 - Background/Aim: Autophagy has been shown to be involved in cancer development and response to cancer therapy. In this study, genotypes of autophagic genes were analyzed to assess their correlation with the risk of clear cell renal cell carcinoma (ccRCC) and the outcome of patients treated with pazopanib for metastatic ccRCC. Materials and Methods: Single nucleotide polymorphisms (SNPs)were selected in the following genes: ATG4A (rs7880351), ATG4B (rs6709768), ATG4C (rs2886770, rs6670694, rs6683832), ATG5 (rs9373839, rs3804333, rs490010), ATG16L1 (rs6752107), ATG16L2 (rs10751215) and IRGM (rs10059011). The Kaplan–Meier method and log-rank test were used to evaluate differences between groups. Results: Forty patients with metastatic ccRCC treated with pazopanib were included in the analysis. ATG16L2rs10751215 was significantly less frequent in patients with ccRCC compared to the general population, suggesting its potential protective role, while ATG4Ars7880351, ATG4C rs6670694 and rs6683832 and ATG5 rs490010 were correlated with the progression-free survival (PFS) of patients treated with pazopanib. Conclusion: Our results suggest, for the first time, that autophagic gene SNPs are associated with ccRCC risk and patient outcome. ER -