TY - JOUR T1 - Intraperitoneal and Systemic Chemotherapy for Patients with Gastric Cancer with Peritoneal Metastasis: A Phase II Trial JF - Anticancer Research JO - Anticancer Res SP - 5975 LP - 5981 DO - 10.21873/anticanres.12945 VL - 38 IS - 10 AU - MASAYUKI SHINKAI AU - MOTOHIRO IMANO AU - YASUTAKA CHIBA AU - YOKO HIRAKI AU - HIROAKI KATO AU - MITSURU IWAMA AU - OSAMU SHIRAISHI AU - ATSUSHI YASUDA AU - MASAHIRO TSUBAKI AU - SHOZO NISHIDA AU - YUTAKA KIMURA AU - TAKUSHI YASUDA Y1 - 2018/10/01 UR - http://ar.iiarjournals.org/content/38/10/5975.abstract N2 - Aim: To conduct a phase II study of single intraperitoneal (i.p.) administration of paclitaxel followed by paclitaxel, cisplatin, and S-1 (PCS) chemotherapy for patients with gastric cancer with peritoneal metastasis (PM). Patients and Methods: Staging laparotomy was performed to confirm PM. Initially, patients received i.p. paclitaxel. Beginning 7 days later, PCS was given every 3 weeks followed by second-look laparoscopy. Primary and secondary endpoints were the overall survival (OS) rate, and response rate and patient safety, respectively. Results: Seventeen patients were enrolled. The overall response rate was 70.5% (12/17). Grade 3/4 toxic effects included neutropenia and leukopenia. After chemotherapy, PM disappearance was confirmed in 11 patients. Gastrectomy was eventually performed in 11 patients. The 1-year OS rate was 82.4% and the median survival time was 23.9 months considering the overall cohort. Conclusion: Combination chemotherapy with i.p. paclitaxel and PCS is well tolerated and effective in patients with gastric cancer with PM. ER -