PT - JOURNAL ARTICLE AU - KOSUKE UEDA AU - SHIGETAKA SUEKANE AU - TAISHI HIRANO AU - NAOYUKI OGASAWARA AU - KATSUAKI CHIKUI AU - KEIICHIRO UEMURA AU - MAKOTO NAKIRI AU - KIYOAKI NISHIHARA AU - MITSUNORI MATSUO AU - TSUKASA IGAWA TI - Efficacy of Axitinib as Second-line Treatment in Locally Advanced and Metastatic Renal Cell Carcinoma AID - 10.21873/anticanres.12868 DP - 2018 Sep 01 TA - Anticancer Research PG - 5387--5392 VI - 38 IP - 9 4099 - http://ar.iiarjournals.org/content/38/9/5387.short 4100 - http://ar.iiarjournals.org/content/38/9/5387.full SO - Anticancer Res2018 Sep 01; 38 AB - Aim: To investigate prognostic factors for patients with advanced renal cell carcinoma (RCC) treated with axitinib as second-line therapy. Patients and Methods: This study included 35 patients with RCC who received axitinib as second-line therapy after the failure of first-line tyrosine kinases inhibitor from November 2012 to March 2017. Results: In univariate analyses, the following factors were associated with poor prognosis: bone and extrapulmonary metastasis for progression-free survival; and prior nephrectomy, Memorial Sloan Kettering Cancer Center risk classification, International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk classification of poor, extrapulmonary metastasis and early tumor response for overall survival. Multivariate analyses identified the following factors as independent poor prognostic effects: extrapulmonary metastasis for progression-free survival, and no prior nephrectomy, IMDC risk classification of poor and extrapulmonary metastasis for overall survival. Conclusion: Axitinib as second-line treatment is effective for patients with pulmonary metastasis alone of RCC, but not for those with extrapulmonary metastasis.