PT  - JOURNAL ARTICLE
AU  - KAWAHARA, HIDEJIRO
AU  - YOSHIDA, SEIYA
AU  - TOHYAMA, YOICHI
AU  - YANAGISAWA, SATORU
AU  - MISAWA, TAKEYUKI
AU  - YANAGA, KATSUHIKO
TI  - Serum Carcinoembryonic Antigen Levels Before the First Curative Hepatectomy for Metastatic Colorectal Cancer Is a Predictor of Recurrence
AID  - 10.21873/anticanres.12863
DP  - 2018 Sep 01
TA  - Anticancer Research
PG  - 5351--5355
VI  - 38
IP  - 9
4099  - http://ar.iiarjournals.org/content/38/9/5351.short
4100  - http://ar.iiarjournals.org/content/38/9/5351.full
SO  - Anticancer Res2018 Sep 01; 38
AB  - Background/Aim: The aim of this study was to evaluate the usefulness of serum carcinoembryonic antigen (CEA) levels before the first curative hepatectomy for metastatic colorectal cancer as a predictor of recurrence. Patients and Methods: Between 2003 and 2010, 66 patients (45 male and 21 female) who underwent a first curative hepatectomy for metastatic colorectal cancer in our hospital were evaluated retrospectively. The mean patient age was 65.2 years (range=31-80 years). A total of 28 patients had synchronous liver metastasis, and the other 38 patients developed metachronous liver metastasis. Results: The 5-year relapse-free survival rate after the first hepatectomy of the 16 patients with normal serum CEA level was 61.1%, whereas that of the 50 patients with abnormal serum CEA level was 34.3% (p<0.001). Among patients whose serum CEA levels were abnormal, the 5-year relapse-free survival rate after the first hepatectomy of the 34 patients with serum CEA levels less than 50 ng/ml was 48.1%, whereas that of the 16 patients with serum CEA level equal to or greater than 50 ng/ml was 6.3% (p<0.001). All eleven patients whose serum CEA levels were at least 100 ng/ml developed recurrence within one year after hepatectomy. Conclusion: Serum CEA levels before the first curative hepatectomy for metastatic colorectal cancer seem to be a predictor of recurrence.