TY - JOUR T1 - The Combination of Neutrophil–to–lymphocyte Ratio and Serum Carbohydrate Antigen 19-9 Level as a Prognostic Indicator in Patients with Recurrent Pancreatic Cancer JF - Anticancer Research JO - Anticancer Res SP - 5497 LP - 5503 DO - 10.21873/anticanres.12883 VL - 38 IS - 9 AU - TERUHISA SAKAMOTO AU - HIROAKI SAITO AU - EI UCHINAKA AU - MASAKI MORIMOTO AU - MASATAKA AMISAKI AU - NARUO TOKUYASU AU - SOICHIRO HONJO AU - KEIGO ASHIDA AU - YOSHIYUKI FUJIWARA Y1 - 2018/09/01 UR - http://ar.iiarjournals.org/content/38/9/5497.abstract N2 - Background/Aim: We retrospectively investigated the relationship between prognosis and combined neutrophil–to–lymphocyte ratio (NLR) and serum carbohydrate antigen 19-9 (CA19-9) levels in patients with recurrent pancreatic cancer. Patients and Methods: We enrolled 66 patients whose pancreatic cancer recurred. Results: Based on ROC analysis results, the patients were divided into NLRHigh (NLR ≥1.69) or NLRLow (NLR <1.69), and into CA19-9High (CA19-9 ≥107.95 U/ml) or CA19-9Low (CA19-9 <107.95 U/ml). When the patients were grouped by combined NLR and CA19-9, their 2-year survival rates were NLRLow/CA19-9Low: 58.7%; NLRLow/CA19-9High or NLRHigh/CA19-9Low (grouped together): 11.2%; and NLRHigh/CA19-9High: 0% (p<0.0001). Finally, in multivariate analysis, the combination of NLR and serum CA19-9 level was an independent prognostic factor in patients with recurrent pancreatic cancer. Conclusion: The combination of NLR and serum CA19-9 level is a useful prognostic indicator for recurrent pancreatic cancer. ER -