RT Journal Article
SR Electronic
T1 Biomarkers of Oxidative Stress Associated with the Risk of Potentially Malignant Oral Disorders
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5211
OP 5216
DO 10.21873/anticanres.12844
VO 38
IS 9
A1 SENGHORE, THOMAS
A1 LI, YU-FENG
A1 SUNG, FUNG-CHANG
A1 TSAI, MING-HSUI
A1 HUA, CHUN-HUNG
A1 LIU, CHIU-SHONG
A1 HUANG, RU-JIUN
A1 YEH, CHIH-CHING
YR 2018
UL http://ar.iiarjournals.org/content/38/9/5211.abstract
AB Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.