PT  - JOURNAL ARTICLE
AU  - THOMAS SENGHORE
AU  - YU-FENG LI
AU  - FUNG-CHANG SUNG
AU  - MING-HSUI TSAI
AU  - CHUN-HUNG HUA
AU  - CHIU-SHONG LIU
AU  - RU-JIUN HUANG
AU  - CHIH-CHING YEH
TI  - Biomarkers of Oxidative Stress Associated with the Risk of Potentially Malignant Oral Disorders
AID  - 10.21873/anticanres.12844
DP  - 2018 Sep 01
TA  - Anticancer Research
PG  - 5211--5216
VI  - 38
IP  - 9
4099  - http://ar.iiarjournals.org/content/38/9/5211.short
4100  - http://ar.iiarjournals.org/content/38/9/5211.full
SO  - Anticancer Res2018 Sep 01; 38
AB  - Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.