TY - JOUR T1 - Association of Matrix Metalloproteinase-8 Genotypes with the Risk of Bladder Cancer JF - Anticancer Research JO - Anticancer Res SP - 5159 LP - 5164 DO - 10.21873/anticanres.12838 VL - 38 IS - 9 AU - TSUNG-HSUN TSAI AU - YAO-MING WANG AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - HSI-CHIN WU AU - HUAI-MEI HSU AU - YUN-CHI WANG AU - HSIN-TING LI AU - CHI-LI GONG AU - DA-TIAN BAU AU - CHI-YUAN LI Y1 - 2018/09/01 UR - http://ar.iiarjournals.org/content/38/9/5159.abstract N2 - Background/Aim: Matrix metalloproteinases (MMPs) control the homeostasis of the extracellular matrix and their genetic polymorphisms may contribute to cancer susceptibility. The aim of this study was to reveal the genotypes of MMP8 among the Taiwanese and examine the contribution of MMP8 C-799T, Val436Ala and Lys460Thr polymorphisms to bladder cancer. Materials and Methods: MMP8 C-799T, Val436Ala and Lys460Thr polymorphic genotypes were determined in 375 patients with bladder cancer and 375 healthy controls by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: Regarding MMP8 C-799T, there was no significant differential distribution between patient and control groups [p for trend=0.6629]. The odds ratios (ORs) after adjusting for age, gender, smoking and alcohol drinking status for those carrying CT and TT genotypes at MMP8 C-799T were 1.13 (95%CI=0.89-1.44, p=0.3688) and 1.10 (95%CI=0.87-1.52, p=0.9030), respectively, compared to those carrying the wild-type CC genotype. Regarding MMP8 Val436Ala, there was no significant differential distribution between patient and control groups [p for trend=0.8166]. The adjusted OR for those carrying AC and CC genotypes at MMP8 Val436Ala were 0.71 (95%CI=0.31-2.28, p=0.6094) and 1.00 (95%CI=0.21-4.73, p=0.7247), respectively. The polymorphism Lys460Thr at MMP8 was not found among Taiwanese patients. Conclusion: MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan. ER -