RT Journal Article SR Electronic T1 Prognostic Significance of Neutrophil–to–lymphocyte Ratio in the Framework of the 8th TNM Edition for Breast Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4705 OP 4712 DO 10.21873/anticanres.12777 VO 38 IS 8 A1 PATRIZIA FERRONI A1 MARIO ROSELLI A1 ORESTE C. BUONOMO A1 ANTONELLA SPILA A1 ILARIA PORTARENA A1 ANASTASIA LAUDISI A1 MARIA G. VALENTE A1 SILVANA P. PIRILLO A1 LUCIO FORTUNATO A1 LEOPOLDO COSTARELLI A1 FRANCESCO CAVALIERE A1 FIORELLA GUADAGNI YR 2018 UL http://ar.iiarjournals.org/content/38/8/4705.abstract AB Background/Aim: To investigate whether neutrophil–to–lymphocyte ratio (NLR) might represent an additional biological criterion able to identify patients with worse prognosis within the 8th edition TNM prognostic staging system for breast cancer (BC). Patients and Methods. Pre-treatment NLR was retrospectively analyzed in 475 BC women prospectively followed for a mean time of 3.8 years. The optimal NLR cutoff, identified by ROC analysis, was set at 2. Results: Elevated pre-treatment NLR was associated with worse disease-free survival (DFS) (HR=2.28) and overall survival (OS) (HR=3.39). The prognostic value of NLR was mostly evident in stage I BC (HR for DFS=2.89; HR for OS=1.30), in whom NLR significantly stratified patients who developed distant metastasis (HR= 4.62), but not local recurrence. Conclusion: NLR might provide important information in risk stratification, especially in stage I BC patients in whom the presence of a high NLR might raise the question as to whether they should be more aggressively managed.