PT  - JOURNAL ARTICLE
AU  - STEFAN FELIX THIEME
AU  - FEDERICO COLLETTINI
AU  - JALID SEHOULI
AU  - LUCIO BIOCCA
AU  - ALESSANDRA LELLA
AU  - MORITZ WAGNER
AU  - JUMANA ALMUHEIMID
AU  - HELMUT PLETT
AU  - MUSTAFA ZELAL MUALLEM
TI  - Preoperative Evaluation of Myometrial Invasion in Endometrial Carcinoma: Prospective Intra-individual Comparison of Magnetic Resonance Volumetry, Diffusion-weighted and Dynamic Contrast-enhanced Magnetic Resonance Imaging
AID  - 10.21873/anticanres.12791
DP  - 2018 Aug 01
TA  - Anticancer Research
PG  - 4813--4817
VI  - 38
IP  - 8
4099  - http://ar.iiarjournals.org/content/38/8/4813.short
4100  - http://ar.iiarjournals.org/content/38/8/4813.full
SO  - Anticancer Res2018 Aug 01; 38
AB  - Aim: The purpose of this prospective study was to compare the diagnostic performance of diffusion-weighted (DWI) and dynamic contrast-enhanced imaging (DCE) and volumetric analyses in the preoperative assessment of myometrial invasion in patients with endometrial carcinoma. Materials and Methods: Thirty-five patients with endometrial cancer underwent preoperative magnetic resonance imaging including DWI and DCE for evaluation of the depth of myometrial invasion and volumetric analyses [tumor volume (TV), uterine volume (UV), tumor to volume ratio (TVR=(TV/TU)×100)]. The results of the evaluations were compared to the histopathological examinations. Results: DWI and DCE showed a sensitivity and specificity in evaluating the depth of myometrial invasion of 92% and 96% and 92% and 86%, respectively, while volumetric analyses showed a sensitivity and specificity of 85% and 86% (TVR cut-off=10%) and 69% and 100% (TVR cut-off=25%), respectively. Conclusion: DWI and DCE are both good diagnostic tools for the preoperative assessment of myometrial invasion. From our results and literature research, there is potential for omitting gadolinium-based contrast agents given the high diagnostic value of DWI. In our patient collective, the predictive power of volumetric analyses was lower than that of DWI.