RT Journal Article
SR Electronic
T1 Pilot Study of Probe-based Confocal Laser Endomicroscopy with Fluorescein-dripping Method for Liver Tumors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4775
OP 4781
DO 10.21873/anticanres.12786
VO 38
IS 8
A1 MORIMOTO, MASAKI
A1 HONJO, SOICHIRO
A1 SAKAMOTO, TERUHISA
A1 UCHINAKA, EI
A1 AMISAKI, MASATAKA
A1 ARAI, YOSUKE
A1 YAMAMOTO, MANABU
A1 FUKUMOTO, YOJI
A1 OSAKI, TOMOHIRO
A1 TOKUYASU, NARUO
A1 ASHIDA, KEIGO
A1 SAITO, HIROAKI
A1 FUJIWARA, YOSHIYUKI
YR 2018
UL http://ar.iiarjournals.org/content/38/8/4775.abstract
AB Background/Aim: Probe-based confocal laser endomicroscopy (pCLE) is a novel diagnostic technique that can provide real-time imaging of tissues at the cellular level. In this study, pCLE was applied to liver tumors and its diagnostic value was evaluated. Patients and Methods: Ten patients who underwent hepatectomy for liver tumors were evaluated with pCLE from February to May 2017. Immediately after liver resection, pCLE evaluation was performed in the operating room as an ex vivo study. The newly-adopted “fluorescein-dripping method” was used for the observation. Results: First, the optimal fluorescein exposure time for the surface of liver was defined in the fluorescein-dripping method. Next, the distinctive findings in the cancerous region were investigated. The characteristic appearance of irregular arrangements of concentrated cells under fluorescein dripping was observed in six of seven hepatocellular carcinoma (HCC) tumors. Conclusion: In all HCC specimens, discrimination of the cancerous region from normal liver was possible with pCLE.