TY - JOUR T1 - Quality of Life Following Stereotactic Body Radiotherapy <em>Versus</em> Three-Dimensional Conformal Radiotherapy for Vertebral Metastases: Secondary Analysis of an Exploratory Phase II Randomized Trial JF - Anticancer Research JO - Anticancer Res SP - 4961 LP - 4968 DO - 10.21873/anticanres.12814 VL - 38 IS - 8 AU - TANJA SPRAVE AU - VIVEK VERMA AU - ROBERT FÖRSTER AU - INGMAR SCHLAMPP AU - THOMAS BRUCKNER AU - TILMAN BOSTEL AU - RAMI ATEAYH EL SHAFIE AU - NILS HENRIK NICOLAY AU - JÜRGEN DEBUS AU - HARALD RIEF Y1 - 2018/08/01 UR - http://ar.iiarjournals.org/content/38/8/4961.abstract N2 - Background/Aim: This was a prespecified secondary analysis of a randomized trial, which analyzed quality of life (QOL), fatigue, and emotional distress following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT) as part of palliative management of painful spinal metastases. Materials and Methods: Fifty-five patients were enrolled in this single-institutional randomized exploratory phase II trial (NCT02358720). Participants were randomly assigned to receive SBRT (single-fraction 24 Gy) or 3DCRT (30 Gy/10 fractions). QOL (EORTC QLQ-BM22), fatigue (EORTC QLQ FA13), and emotional distress (QSC-R10) at the end of radiotherapy, along with 3- and 6-month follow-up were assessed. Results: At all recorded time points, there were no significant QOL differences between cohorts, including painful sites, pain characteristics, functional impairment, or psychosocial aspects (p&gt;0.05 for all). There were also no differences in all dimensions of fatigue between groups at each recorded time point (p&gt;0.05 for all). Emotional distress was also similar at three (p=0.248) and six months (p=0.603). Conclusion: Although these results demonstrate that SBRT does not cause worse QOL deteriorations compared to 3DCRT, larger randomized investigations are recommended to corroborate these findings. ER -