PT - JOURNAL ARTICLE AU - JURGITA JURŠĖNAITĖ AU - IRUTĖ GIRKONTAITĖ AU - ALMANTAS ŠIAURYS AU - MYKOLAS MAURICAS AU - DAINIUS CHARACIEJUS TI - Intratumoral Accumulation and Clonal Expansion May Not Be Decisive for Rejection of Allogeneic Tumors by CD8<sup>+</sup> T-Lymphocytes AID - 10.21873/anticanres.12751 DP - 2018 Aug 01 TA - Anticancer Research PG - 4481--4484 VI - 38 IP - 8 4099 - http://ar.iiarjournals.org/content/38/8/4481.short 4100 - http://ar.iiarjournals.org/content/38/8/4481.full SO - Anticancer Res2018 Aug 01; 38 AB - Background: The aim of this study was to analyze the spatial distribution and proliferation of adoptively transferred CD8+ T-lymphocytes sensitized against allogeneic tumors. Materials and Methods: Transgenic β-actin-luc mice that express luciferase were sensitized against allogeneic SL2 lymphoma. CD8+ T-lymphocytes from these mice were transferred to lymphocyte-deficient, recombination activating gene-deficient (Rag−/−) mice bearing SL2 tumors and were tracked using bioluminescence imaging. Results: Two out of six Rag−/− mice rejected their tumors. There were no apparent differences in spatial distribution and proliferative intensity of adoptively-transferred CD8+ T-lymphocytes between the two Rag−/− mice that rejected allogeneic SL2 tumors and the four Rag−/− mice that did not. Conclusion: The pattern of distribution in the mouse body and proliferative intensity of CD8+ T-lymphocytes do not seem to be decisive factors influencing allogeneic tumor rejection.