RT Journal Article
SR Electronic
T1 Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4515
OP 4523
DO 10.21873/anticanres.12755
VO 38
IS 8
A1 MASUDA, TAKAAKI
A1 SHINDEN, YOSHIAKI
A1 NODA, MIWA
A1 UEO, HIROKI
A1 HU, QINGJIANG
A1 YOSHIKAWA, YUKIHIRO
A1 TSURUDA, YUSUKE
A1 KURODA, YOSUKE
A1 ITO, SHUHEI
A1 EGUCHI, HIDETOSHI
A1 OHNO, SHINJI
A1 MIMORI, KOSHI
YR 2018
UL http://ar.iiarjournals.org/content/38/8/4515.abstract
AB Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for “Precision medicine”. This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgically-treated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.