TY - JOUR T1 - Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 4515 LP - 4523 DO - 10.21873/anticanres.12755 VL - 38 IS - 8 AU - TAKAAKI MASUDA AU - YOSHIAKI SHINDEN AU - MIWA NODA AU - HIROKI UEO AU - QINGJIANG HU AU - YUKIHIRO YOSHIKAWA AU - YUSUKE TSURUDA AU - YOSUKE KURODA AU - SHUHEI ITO AU - HIDETOSHI EGUCHI AU - SHINJI OHNO AU - KOSHI MIMORI Y1 - 2018/08/01 UR - http://ar.iiarjournals.org/content/38/8/4515.abstract N2 - Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for “Precision medicine”. This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgically-treated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients. ER -