PT  - JOURNAL ARTICLE
AU  - MASUDA, TAKAAKI
AU  - SHINDEN, YOSHIAKI
AU  - NODA, MIWA
AU  - UEO, HIROKI
AU  - HU, QINGJIANG
AU  - YOSHIKAWA, YUKIHIRO
AU  - TSURUDA, YUSUKE
AU  - KURODA, YOSUKE
AU  - ITO, SHUHEI
AU  - EGUCHI, HIDETOSHI
AU  - OHNO, SHINJI
AU  - MIMORI, KOSHI
TI  - Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer
AID  - 10.21873/anticanres.12755
DP  - 2018 Aug 01
TA  - Anticancer Research
PG  - 4515--4523
VI  - 38
IP  - 8
4099  - http://ar.iiarjournals.org/content/38/8/4515.short
4100  - http://ar.iiarjournals.org/content/38/8/4515.full
SO  - Anticancer Res2018 Aug 01; 38
AB  - Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for “Precision medicine”. This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgically-treated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.