<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MASUDA, TAKAAKI</style></author><author><style face="normal" font="default" size="100%">SHINDEN, YOSHIAKI</style></author><author><style face="normal" font="default" size="100%">NODA, MIWA</style></author><author><style face="normal" font="default" size="100%">UEO, HIROKI</style></author><author><style face="normal" font="default" size="100%">HU, QINGJIANG</style></author><author><style face="normal" font="default" size="100%">YOSHIKAWA, YUKIHIRO</style></author><author><style face="normal" font="default" size="100%">TSURUDA, YUSUKE</style></author><author><style face="normal" font="default" size="100%">KURODA, YOSUKE</style></author><author><style face="normal" font="default" size="100%">ITO, SHUHEI</style></author><author><style face="normal" font="default" size="100%">EGUCHI, HIDETOSHI</style></author><author><style face="normal" font="default" size="100%">OHNO, SHINJI</style></author><author><style face="normal" font="default" size="100%">MIMORI, KOSHI</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4515-4523</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.12755</style></doi><volume><style face="normal" font="default" size="100%">38</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for “Precision medicine”. This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgically-treated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.</style></abstract></record></records></xml>