RT Journal Article SR Electronic T1 Particle Stability During Pressurized Intra-peritoneal Aerosol Chemotherapy (PIPAC) JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4645 OP 4649 DO 10.21873/anticanres.12769 VO 38 IS 8 A1 AGATA MIKOLAJCZYK A1 VERIA KHOSRAWIPOUR A1 JUSTYNA SCHUBERT A1 HARIS CHAUDHRY A1 ALESSIO PIGAZZI A1 TANJA KHOSRAWIPOUR YR 2018 UL http://ar.iiarjournals.org/content/38/8/4645.abstract AB Background/Aim: Pressurized intra-peritoneal aerosol chemotherapy (PIPAC) is a new approach in the treatment of peritoneal carcinomatosis. With PIPAC currently limited to liquid chemotherapeutic solutions, this study aims to investigate whether the application range may be extended to the delivery of therapeutic nano- or microparticles. Materials and Methods: Human serum, bacteria cultures and macrophage cells were aerosolized in an established ex vivo model. Human serum composition was analyzed via gel electrophoresis. The viability of bacteria and macrophage cells was measured prior to and following PIPAC. Results: No structural disintegration of the plasma solution was detected. While the concentration and viability of Escherichia coli and Salmonella Enteritidis did not significantly change following aerosol formation, macrophage cells showed structural disintegration. Conclusion: Our ex vivo data suggest that PIPAC can be used to deliver complex particles. The delivery of small and less complex particles was feasible, yet the mechanical and physical properties of PIPAC might alter the stability of larger and more complex particles.