TY - JOUR T1 - Neoadjuvant Radiotherapy with Capecitabine Plus Bevacizumab for Locally Advanced Lower Rectal Cancer: Results of a Single-institute Phase II Study JF - Anticancer Research JO - Anticancer Res SP - 4193 LP - 4197 DO - 10.21873/anticanres.12713 VL - 38 IS - 7 AU - KIYOSHI MAEDA AU - MASATSUNE SHIBUTANI AU - HIROSHI OTANI AU - TATSUNARI FUKUOKA AU - YASUHITO ISEKI AU - SHINJI MATSUTANI AU - HISASHI NAGAHARA AU - TORU INOUE AU - AKIKO TACHIMORI AU - TAKAFUMI NISHII AU - YOSHITAKA MIKI AU - MASAKO HOSONO AU - MASAICHI OHIRA Y1 - 2018/07/01 UR - http://ar.iiarjournals.org/content/38/7/4193.abstract N2 - Background/Aim: A single-arm phase II clinical trial was conducted to evaluate the safety and efficacy of adding bevacizumab to standard capecitabine-based neoadjuvant chemoradiotherapy (CRT) for the treatment of locally advanced rectal cancer (LARC). Patients and Methods: Twenty-five patients were enrolled. Patients received capecitabine-based CRT for 5 weeks and 3 days. Bevacizumab was administered every 2 weeks during CRT. Within 6-10 weeks after completion of CRT, surgery was performed. Results: With regard to CRT-related acute toxicities, most of the adverse events were limited to grade 1. A pathological complete response was obtained in four (16%) patients. In total, six patients (24%) developed postoperative complications. Six out of five (83%) patients healed without the need for surgical intervention. Conclusion: Although acute toxicity during CRT with bevacizumab was minimal and postoperative complications do not seem to increase, the addition of bevacizumab apparently offers no clinically-significant benefit for patients with LARC. ER -