@article {MAEDA4193, author = {KIYOSHI MAEDA and MASATSUNE SHIBUTANI and HIROSHI OTANI and TATSUNARI FUKUOKA and YASUHITO ISEKI and SHINJI MATSUTANI and HISASHI NAGAHARA and TORU INOUE and AKIKO TACHIMORI and TAKAFUMI NISHII and YOSHITAKA MIKI and MASAKO HOSONO and MASAICHI OHIRA}, title = {Neoadjuvant Radiotherapy with Capecitabine Plus Bevacizumab for Locally Advanced Lower Rectal Cancer: Results of a Single-institute Phase II Study}, volume = {38}, number = {7}, pages = {4193--4197}, year = {2018}, doi = {10.21873/anticanres.12713}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: A single-arm phase II clinical trial was conducted to evaluate the safety and efficacy of adding bevacizumab to standard capecitabine-based neoadjuvant chemoradiotherapy (CRT) for the treatment of locally advanced rectal cancer (LARC). Patients and Methods: Twenty-five patients were enrolled. Patients received capecitabine-based CRT for 5 weeks and 3 days. Bevacizumab was administered every 2 weeks during CRT. Within 6-10 weeks after completion of CRT, surgery was performed. Results: With regard to CRT-related acute toxicities, most of the adverse events were limited to grade 1. A pathological complete response was obtained in four (16\%) patients. In total, six patients (24\%) developed postoperative complications. Six out of five (83\%) patients healed without the need for surgical intervention. Conclusion: Although acute toxicity during CRT with bevacizumab was minimal and postoperative complications do not seem to increase, the addition of bevacizumab apparently offers no clinically-significant benefit for patients with LARC.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/7/4193}, eprint = {https://ar.iiarjournals.org/content/38/7/4193.full.pdf}, journal = {Anticancer Research} }