TY - JOUR T1 - Efficacy and Safety of Sorafenib in a Racially Diverse Patient Population with Advanced Hepatocellular Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 4027 LP - 4034 DO - 10.21873/anticanres.12691 VL - 38 IS - 7 AU - TIMOTHY M. SCHMIDT AU - LI LIU AU - IVY E. ABRAHAM AU - ALMAE B. UY AU - ARKADIUSZ Z. DUDEK Y1 - 2018/07/01 UR - http://ar.iiarjournals.org/content/38/7/4027.abstract N2 - Background: There are few efficacy and toxicity data on sorafenib for patients treated for hepatocellular carcinoma (HCC) who are not Caucasian or Asian. Materials and Methods: A retrospective analysis was carried out on 67 patients treated with sorafenib for advanced HCC at an urban referral center. Patients were categorized by race, age, sex, status, stage, and dose. Primary outcomes were time to progression (TTP), toxicity, and treatment discontinuation by race. Results: African-Americans and Caucasians had significantly shorter TTP than patients of other races (Hispanic, Asian, and unidentified) [African-Americans: hazard ratio (HR)=5.01, p=0.0068; Caucasians: HR=8.25, p=0.0008). There were no significant differences in time to toxicity (p=0.99). Caucasians had the shortest time to therapy discontinuation (p=0.0298). TTP was shorter for males (HR=3.51, p=0.028), and longer for patients experiencing toxicity (HR=0.47, p=0.046). Conclusion: Among patients treated with sorafenib for advanced HCC, non African-American/non-Caucasian race, female sex, and toxicity were associated with significantly longer time to progression. ER -