PT  - JOURNAL ARTICLE
AU  - TIMOTHY M. SCHMIDT
AU  - LI LIU
AU  - IVY E. ABRAHAM
AU  - ALMAE B. UY
AU  - ARKADIUSZ Z. DUDEK
TI  - Efficacy and Safety of Sorafenib in a Racially Diverse Patient Population with Advanced Hepatocellular Carcinoma
AID  - 10.21873/anticanres.12691
DP  - 2018 Jul 01
TA  - Anticancer Research
PG  - 4027--4034
VI  - 38
IP  - 7
4099  - http://ar.iiarjournals.org/content/38/7/4027.short
4100  - http://ar.iiarjournals.org/content/38/7/4027.full
SO  - Anticancer Res2018 Jul 01; 38
AB  - Background: There are few efficacy and toxicity data on sorafenib for patients treated for hepatocellular carcinoma (HCC) who are not Caucasian or Asian. Materials and Methods: A retrospective analysis was carried out on 67 patients treated with sorafenib for advanced HCC at an urban referral center. Patients were categorized by race, age, sex, status, stage, and dose. Primary outcomes were time to progression (TTP), toxicity, and treatment discontinuation by race. Results: African-Americans and Caucasians had significantly shorter TTP than patients of other races (Hispanic, Asian, and unidentified) [African-Americans: hazard ratio (HR)=5.01, p=0.0068; Caucasians: HR=8.25, p=0.0008). There were no significant differences in time to toxicity (p=0.99). Caucasians had the shortest time to therapy discontinuation (p=0.0298). TTP was shorter for males (HR=3.51, p=0.028), and longer for patients experiencing toxicity (HR=0.47, p=0.046). Conclusion: Among patients treated with sorafenib for advanced HCC, non African-American/non-Caucasian race, female sex, and toxicity were associated with significantly longer time to progression.