RT Journal Article
SR Electronic
T1 In Vitro Anticancer Activities of B6 Vitamers: A Mini-review
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3429
OP 3432
DO 10.21873/anticanres.13488
VO 39
IS 7
A1 TAISUKE MATSUO
A1 YASUYUKI SADZUKA
YR 2019
UL http://ar.iiarjournals.org/content/39/7/3429.abstract
AB Vitamin B6 compounds, including pyridoxine, pyridoxal, pyridoxamine, and their phosphorylated forms, have been investigated with regard to their cancer preventive and therapeutic effects through epidemiological, in vivo, and in vitro studies. In particular, in vitro studies in cancer cells have evaluated the effects of several B6 vitamers such as pyridoxine, pyridoxal, pyridoxamine, and pyridoxal-5’-phosphate, which is a bioactive form of vitamin B6. However, the anticancer activity and concentration required to influence cancer cells vary among B6 vitamers. In this review, the various in vitro effects of vitamin B6 compounds on cancer cells are presented and discussed.