RT Journal Article
SR Electronic
T1 Pleiotropic Chemotherapy to Abrogate Glioblastoma Multiforme Migration/Invasion
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3423
OP 3427
DO 10.21873/anticanres.13487
VO 39
IS 7
A1 LAWRENCE HELSON
A1 MUHAMMED MAJEED
YR 2019
UL http://ar.iiarjournals.org/content/39/7/3423.abstract
AB Current clinical failure to cure primary glioblastoma multiforme in virtually all adult patients is due to genetic aberrations, molecular heterogeneity, and clonal evolution of tumor stem and differentiated cells within the core tumor, leading to their migration, invasion and proliferation in normal surrounding and in distant cerebral tissue sites. These factors are the causes of targeted drug resistance, inadequate surgical removal, and inadequate radio-therapeutic interventions. Resolution of this clinical conundrum may be found in administration of Withaferin A alone or in combination with pleiotropic drugs which address aberrant molecules and pathways promoting tumor cell motility, migration, invasion and proliferation.