PT  - JOURNAL ARTICLE
AU  - JUDYTA ZABIELSKA
AU  - TOMASZ SLEDZINSKI
AU  - EWA STELMANSKA
TI  - Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment
AID  - 10.21873/anticanres.13482
DP  - 2019 Jul 01
TA  - Anticancer Research
PG  - 3385--3394
VI  - 39
IP  - 7
4099  - http://ar.iiarjournals.org/content/39/7/3385.short
4100  - http://ar.iiarjournals.org/content/39/7/3385.full
SO  - Anticancer Res2019 Jul 01; 39
AB  - Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment. Inhibition of ACAT results in suppression of proliferation in a range of cancer cell types both in vitro and in vivo. The exact mechanism of this phenomenon is being investigated, and the most important findings are presented in this review.