@article {ZABIELSKA3385, author = {JUDYTA ZABIELSKA and TOMASZ SLEDZINSKI and EWA STELMANSKA}, title = {Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment}, volume = {39}, number = {7}, pages = {3385--3394}, year = {2019}, doi = {10.21873/anticanres.13482}, publisher = {International Institute of Anticancer Research}, abstract = {Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment. Inhibition of ACAT results in suppression of proliferation in a range of cancer cell types both in vitro and in vivo. The exact mechanism of this phenomenon is being investigated, and the most important findings are presented in this review.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/39/7/3385}, eprint = {https://ar.iiarjournals.org/content/39/7/3385.full.pdf}, journal = {Anticancer Research} }