PT  - JOURNAL ARTICLE
AU  - GADDUCCI, ANGIOLO
AU  - GIULIANI, DANIELA
AU  - COSIO, STEFANIA
AU  - LISSONI, ANDREA
AU  - FERRERO, ANNA MARIA
AU  - LANDONI, FABIO
TI  - Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study
AID  - 10.21873/anticanres.13372
DP  - 2019 May 01
TA  - Anticancer Research
PG  - 2513--2517
VI  - 39
IP  - 5
4099  - http://ar.iiarjournals.org/content/39/5/2513.short
4100  - http://ar.iiarjournals.org/content/39/5/2513.full
SO  - Anticancer Res2019 May 01; 39
AB  - Background/Aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma. Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma. Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively. Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.