RT Journal Article
SR Electronic
T1 Hyperthermia Suppresses Post - <em>In Vitro</em> Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2307
OP 2315
DO 10.21873/anticanres.13347
VO 39
IS 5
A1 THEODORA MANTSO
A1 STAVROS VASILEIADIS
A1 EVANGELI LAMPRI
A1 SOTIRIS BOTAITIS
A1 SEBACHEDIN PERENTE
A1 CONSTANTINOS SIMOPOULOS
A1 KATERINA CHLICHLIA
A1 AGLAIA PAPPA
A1 MIHALIS I. PANAYIOTIDIS
YR 2019
UL http://ar.iiarjournals.org/content/39/5/2307.abstract
AB Background: Several studies have highlighted hyperthermia's ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. Materials and Methods: In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia's therapeutic effectiveness by examining levels of caspase 3, COX-2 and phospho-H2A.X (Ser139) as endpoints of apoptosis, proliferation and DNA damage respectively. Results: Hyperthermia induced in vitro cytotoxicity in malignant melanoma (B16-F10) and colon carcinoma (CT26) cell lines. In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. Conclusion: Hyperthermia can exert therapeutic effectiveness against melanoma and colon carcinoma by inhibiting a number of critical cellular cascades including apoptosis, proliferation and DNA damage.