PT  - JOURNAL ARTICLE
AU  - AYAKO TAMAGAWA
AU  - TORU AOYAMA
AU  - HIROSHI TAMAGAWA
AU  - MIHWA JU
AU  - KEISUKE KOMORI
AU  - YUKIO MAEZAWA
AU  - KAZUKI KANO
AU  - KEISUKE KAZAMA
AU  - MASAAKI MURAKAWA
AU  - YOSUKE ATSUMI
AU  - SHO SAWAZAKI
AU  - KENTARO HARA
AU  - MASAKATSU NUMATA
AU  - TSUTOMU SATO
AU  - NORIO YUKAWA
AU  - MUNETAKA MASUDA
AU  - YASUSHI RINO
TI  - Influence of Postoperative Pneumonia on Esophageal Cancer Survival and Recurrence
AID  - 10.21873/anticanres.13392
DP  - 2019 May 01
TA  - Anticancer Research
PG  - 2671--2678
VI  - 39
IP  - 5
4099  - http://ar.iiarjournals.org/content/39/5/2671.short
4100  - http://ar.iiarjournals.org/content/39/5/2671.full
SO  - Anticancer Res2019 May 01; 39
AB  - Background/Aim: Postoperative pneumonia after esophageal cancer can lead to additional pain, prolonged hospital stay, and respiratory failure. These adverse events might lead to early recurrence and/or death. We investigated the influence of postoperative pneumonia on the esophageal cancer survival and recurrence after curative surgery. Patients and Methods: This study included 122 patients who underwent curative surgery for esophageal cancer between 2008 and 2018. The patients were classified into: i) those with postoperative pneumonia (pneumonia group) and ii) those without postoperative pneumonia (non-pneumonia group). The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified. The rate of postoperative pneumonia was measured by the revised Uniform Pneumonia Score. Results: Postoperative complications were found in 34 of the 122 patients (27.9%). The OS rate at 5 years following surgery was 28.2% in the pneumonia group and 55.1% in the non-pneumonia group (p=0.006). The RFS rate at 5 years after surgery was 18.9% in the pneumonia group and 49.2% in the non-pneumonia group (p=0.061). A multivariate analysis showed that postoperative pneumonia was a significant independent risk factor for OS. Conclusion: The development of postoperative pneumonia was a risk factor for a decreased overall survival in patients who underwent curative surgery for esophageal cancer. The surgical procedure, perioperative care and surgical strategy should be carefully planned in order to avoid postoperative pneumonia.