TY - JOUR T1 - Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan JF - Anticancer Research JO - Anticancer Res SP - 2791 LP - 2797 DO - 10.21873/anticanres.13406 VL - 39 IS - 6 AU - MING-HSIEN WU AU - YI-WEN HUNG AU - CHI-LI GONG AU - CHI-CHANG CHAO AU - TE-CHENG YUEH AU - SHOU-CHENG WANG AU - YI-LIANG LAI AU - SHIH-WEI HSU AU - CHUN-KAI FU AU - YUN-CHI WANG AU - TAO-WEI KE AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - DA-TIAN BAU Y1 - 2019/06/01 UR - http://ar.iiarjournals.org/content/39/6/2791.abstract N2 - Background/Aim: The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls. Materials and Methods: The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined. Results: The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status. Conclusion: Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. ER -