TY - JOUR T1 - ARID3A Positivity Correlated With Favorable Prognosis in Patients With Residual Rectal Cancer After Neoadjuvant Chemoradiotherapy JF - Anticancer Research JO - Anticancer Res SP - 2845 LP - 2853 DO - 10.21873/anticanres.13413 VL - 39 IS - 6 AU - GHILSUK YOON AU - JEE YOUNG PARK AU - HYE JIN KIM AU - GYU SEOG CHOI AU - JONG GWANG KIM AU - BYUNG WOOG KANG AU - MIN KYU KANG AU - AN NA SEO Y1 - 2019/06/01 UR - http://ar.iiarjournals.org/content/39/6/2845.abstract N2 - Background/Aim: Recent studies have shown a marked increase of AT-rich interactive domain 3A (ARID3A) in colon cancer tissue compared to normal colon mucosa. However, the role of ARID3A has not yet been determined in rectal cancer. We, therefore, investigated the clinical relevance of ARID3A expression in patients with residual rectal cancer after neoadjuvant chemoradiotherapy (NACRT). Materials and Methods: One hundred thirty-four patients who underwent surgical resection for residual rectal cancer after NACRT were analyzed. ARID3A expression was evaluated using immunohistochemistry on whole-tissue sections. KRAS exon 2 (codons 12 and 13) and BRAF V600E mutation status were determined using polymerase chain reaction. Results: ARID3A positivity was found in 91 cases (64.5%), and it correlated with absence of perineural invasion (p=0.031), longer disease-free survival (DFS) (p=0.048) and cancer-specific survival (CSS) (p=0.006). However, ARID3A positivity was not correlated with KRAS (p=0.231) or BRAF mutation status (p=0.577). In multivariate analysis, ARID3A positivity was independently associated with a favorable CSS (p=0.035), but not DFS (p=0.051). Conclusion: ARID3A positivity can predict favorable prognosis in patients with residual rectal cancer after NACRT. ER -