TY - JOUR T1 - Multidisciplinary Therapy for Locally Advanced Oesophageal Cancer With Special Reference to Surgical Conversion and Salvage JF - Anticancer Research JO - Anticancer Res SP - 3167 LP - 3175 DO - 10.21873/anticanres.13454 VL - 39 IS - 6 AU - MAKOTO SOHDA AU - TATSUYA MIYAZAKI AU - MAKOTO SAKAI AU - YUJI KUMAKURA AU - HIROAKI HONJYO AU - KEIGO HARA AU - NARITAKA TANAKA AU - TAKEHIKO YOKOBORI AU - KEN SHIRABE Y1 - 2019/06/01 UR - http://ar.iiarjournals.org/content/39/6/3167.abstract N2 - Background/Aim: Unresectable oesophageal cancer with surrounding invasion carries a particularly poor prognosis. The chemoradiotherapy treatment for locally-unresectable oesophageal cancer aims to initially control local invasion before proceeding to the next treatment, and is ideally used with curative intent. The aim of this study was to investigate patient treatment course and survival to determine the best treatment and evaluate surgical intervention for these advanced cancers. Patients and Methods: A total of 147 patients who were diagnosed with clinical T4b oesophageal cancer were included in this study. Results: Forty-three patients had undergone curative resection of the tumour and surrounding invasion at midterm evaluation, 104 patients continued with definitive chemoradiotherapy, and salvage surgery was performed in 21 patients. Multivariate analysis of disease-specific survival showed that response at the midterm evaluation and surgical intervention (conversion surgery + salvage surgery) were significant prognostic factors. Conclusion: Surgical intervention was an independent prognostic factor, and operation should be performed in eligible patients after considering the risks and proper timing. ER -