TY - JOUR T1 - IGFBP1 Is a Predictive Factor for Haematogenous Metastasis in Patients With Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 2829 LP - 2837 DO - 10.21873/anticanres.13411 VL - 39 IS - 6 AU - YUYA SATO AU - MIKITO INOKUCHI AU - YOKO TAKAGI AU - KAZUYUKI KOJIMA Y1 - 2019/06/01 UR - http://ar.iiarjournals.org/content/39/6/2829.abstract N2 - Background/Aim: The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis. Materials and Methods: The correlation of IGFBP1 expression with the clinicopathological factors and the correlation of clinicopathogical factors with haematogenous metastasis in 219 gastric cancer patients who underwent surgery was examined. Results: High IGFBP1 expression was significantly associated with a poorer disease-specific survival (p<0.001) and relapse-free survival (p<0.001) in univariable analysis although IGFBP1 was not an independent prognostic factor. High IGFBP1 expression was the only independent risk factor of haematogenous metastasis. Conclusion: High IGFBP1 expression was associated with haematogenous metastasis and poor survival. IGFBP1 might become a new prognostic factor and a target of molecular targeted therapy of gastric cancer. ER -