RT Journal Article
SR Electronic
T1 IGFBP1 Is a Predictive Factor for Haematogenous Metastasis in Patients With Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2829
OP 2837
DO 10.21873/anticanres.13411
VO 39
IS 6
A1 YUYA SATO
A1 MIKITO INOKUCHI
A1 YOKO TAKAGI
A1 KAZUYUKI KOJIMA
YR 2019
UL http://ar.iiarjournals.org/content/39/6/2829.abstract
AB Background/Aim: The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis. Materials and Methods: The correlation of IGFBP1 expression with the clinicopathological factors and the correlation of clinicopathogical factors with haematogenous metastasis in 219 gastric cancer patients who underwent surgery was examined. Results: High IGFBP1 expression was significantly associated with a poorer disease-specific survival (p<0.001) and relapse-free survival (p<0.001) in univariable analysis although IGFBP1 was not an independent prognostic factor. High IGFBP1 expression was the only independent risk factor of haematogenous metastasis. Conclusion: High IGFBP1 expression was associated with haematogenous metastasis and poor survival. IGFBP1 might become a new prognostic factor and a target of molecular targeted therapy of gastric cancer.