PT  - JOURNAL ARTICLE
AU  - YUYA SATO
AU  - MIKITO INOKUCHI
AU  - YOKO TAKAGI
AU  - KAZUYUKI KOJIMA
TI  - IGFBP1 Is a Predictive Factor for Haematogenous Metastasis in Patients With Gastric Cancer
AID  - 10.21873/anticanres.13411
DP  - 2019 Jun 01
TA  - Anticancer Research
PG  - 2829--2837
VI  - 39
IP  - 6
4099  - http://ar.iiarjournals.org/content/39/6/2829.short
4100  - http://ar.iiarjournals.org/content/39/6/2829.full
SO  - Anticancer Res2019 Jun 01; 39
AB  - Background/Aim: The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis. Materials and Methods: The correlation of IGFBP1 expression with the clinicopathological factors and the correlation of clinicopathogical factors with haematogenous metastasis in 219 gastric cancer patients who underwent surgery was examined. Results: High IGFBP1 expression was significantly associated with a poorer disease-specific survival (p<0.001) and relapse-free survival (p<0.001) in univariable analysis although IGFBP1 was not an independent prognostic factor. High IGFBP1 expression was the only independent risk factor of haematogenous metastasis. Conclusion: High IGFBP1 expression was associated with haematogenous metastasis and poor survival. IGFBP1 might become a new prognostic factor and a target of molecular targeted therapy of gastric cancer.