PT  - JOURNAL ARTICLE
AU  - PIPOP SAEJIA
AU  - KRIENGSAK LIRDPRAPAMONGKOL
AU  - JISNUSON SVASTI
AU  - N. MONIQUE PARICHARTTANAKUL
TI  - Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-κB and Matrix Metalloproteinase-2 Activation
AID  - 10.21873/anticanres.13360
DP  - 2019 May 01
TA  - Anticancer Research
PG  - 2429--2435
VI  - 39
IP  - 5
4099  - http://ar.iiarjournals.org/content/39/5/2429.short
4100  - http://ar.iiarjournals.org/content/39/5/2429.full
SO  - Anticancer Res2019 May 01; 39
AB  - Background/Aim: Perfluorooctanoic acid (PFOA) is one of the most common perfluorinated compounds widely used in several applications. Due to its persistence in the environment, PFOA has been associated with various diseases, including cancer. This study explored the effects of PFOA on follicular thyroid carcinoma cells (FTC133). Materials and Methods: Cell invasion, migration, adhesion and activity of matrix metalloproteinase-2 (MMP-2) were investigated using Transwell assays, adhesion assay and gelatin zymography, respectively. The underlying mechanism involved in the effects observed was evaluated by immunoblot analyses. Results: Treatment with PFOA did not affect cell migration, but enhanced cell invasion, adhesion and activity of MMP-2 in FTC133 cells. PFOA selectively enhanced the phosphorylation of nuclear factor kappa B (NF-κB) p65, as well as induced NF-κB nuclear translocation. Treatment with a NF-κB inhibitor (BAY 11-7085) was able to reverse PFOA-induced cell invasiveness. Conclusion: PFOA promotes invasiveness of FTC133 cells mediated through the activation of NF-κB signaling.