TY - JOUR T1 - Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-κB and Matrix Metalloproteinase-2 Activation JF - Anticancer Research JO - Anticancer Res SP - 2429 LP - 2435 DO - 10.21873/anticanres.13360 VL - 39 IS - 5 AU - PIPOP SAEJIA AU - KRIENGSAK LIRDPRAPAMONGKOL AU - JISNUSON SVASTI AU - N. MONIQUE PARICHARTTANAKUL Y1 - 2019/05/01 UR - http://ar.iiarjournals.org/content/39/5/2429.abstract N2 - Background/Aim: Perfluorooctanoic acid (PFOA) is one of the most common perfluorinated compounds widely used in several applications. Due to its persistence in the environment, PFOA has been associated with various diseases, including cancer. This study explored the effects of PFOA on follicular thyroid carcinoma cells (FTC133). Materials and Methods: Cell invasion, migration, adhesion and activity of matrix metalloproteinase-2 (MMP-2) were investigated using Transwell assays, adhesion assay and gelatin zymography, respectively. The underlying mechanism involved in the effects observed was evaluated by immunoblot analyses. Results: Treatment with PFOA did not affect cell migration, but enhanced cell invasion, adhesion and activity of MMP-2 in FTC133 cells. PFOA selectively enhanced the phosphorylation of nuclear factor kappa B (NF-κB) p65, as well as induced NF-κB nuclear translocation. Treatment with a NF-κB inhibitor (BAY 11-7085) was able to reverse PFOA-induced cell invasiveness. Conclusion: PFOA promotes invasiveness of FTC133 cells mediated through the activation of NF-κB signaling. ER -