TY - JOUR T1 - Association of <em>SDF-1</em> and <em>CXCR4</em> Polymorphisms With Susceptibility to Oral and Pharyngeal Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2891 LP - 2902 DO - 10.21873/anticanres.13418 VL - 39 IS - 6 AU - SIN-JHIH HUANG AU - YU-KAI TSENG AU - YI-HAO LO AU - PI-CHUANG WU AU - JANG-HWA LEE AU - HUEI-HAN LIOU AU - CHI-CHUANG LIANG AU - CHENG-MEI YANG AU - CHENG-CHING WANG AU - LIANG-MING YEN AU - YUN-CHUNG LIN AU - MIN-HSI LIN AU - LUO-PING GER AU - KUO-WANG TSAI Y1 - 2019/06/01 UR - http://ar.iiarjournals.org/content/39/6/2891.abstract N2 - Background/Aim: Long-term exposure to betel quid (BQ)-, cigarette-, and alcohol-induced chronic inflammation is a crucial risk factor for oral and pharyngeal squamous cell carcinoma (OPSCC) progression. We analyzed the genotypes of stromal-cell-derived factor-1 (SDF-1) and CXC-chemokine receptor-4 (CXCR4) and determined the association between their polymorphisms and the risk of OPSCC. Materials and Methods: This study consisted of 452 patients with pathologically proved OPSCC and 424 sex- and age-matched cancer-free controls. The genotypes of SDF-1 and CXCR4 were detected through the TaqMan real-time polymerase chain reaction (PCR) method. Results: Our data indicated that the C allele and C/C genotypes of CXCR4 were significantly associated with OPSCC [adjusted odds ratio (AOR)=1.41, 95% confidence interval (CI):1.02-1.96, p=0.037 and AOR=1.51, 95% CI:1.05-2.17, p=0.028, respectively] and OSCC (AOR=1.41, 95%CI:1.00-2.00, p=0.049 and AOR=1.49, 95%CI:1.01-2.20, p=0.044, respectively) risk. Patients with genetic polymorphisms of the genotype combination SDF-1/CXCR4 had a higher risk of OSCC (p trend=0.033). We analyzed the effects of CXCR4 genetic variants on susceptibility to OPSCC in patients with different risk habits of BQ chewing, tobacco smoking and alcohol consumption, and revealed that C/T+T/T genotypes exerted an increased risk only in patients with one (AOR=2.68, p=0.036) or two risk habits (AOR=2.02, p=0.027) compared to patients with the C/C genotype. Conclusion: We concluded that CXCR4 C&gt;T can be used as a genetic marker of susceptibility to OPSCC, particularly in OPSCC patients with one or two types of risk habits with a synergistic effect. ER -